منابع مشابه
ob gene mutations and human obesity.
Whilst recent changes in the prevalence of human obesity point to the importance of environmental determinants, genetic susceptibility has been identified as a major contributing factor (Bouchard, 1996). A number of monogenic and polygenic effects are likely to be involved, with their expression likely to vary with diet and the level of physical activity. These genetic influences are not confin...
متن کاملWnt10b inhibits obesity in ob/ob and agouti mice.
The Wnt family of secreted signaling molecules has profound effects on diverse developmental processes, including the fate of mesenchymal progenitors. While activation of Wnt signaling blocks adipogenesis, inhibition of endogenous Wnt/beta-catenin signaling by Wnt10b promotes spontaneous preadipocyte differentiation. Transgenic mice with expression of Wnt10b from the FABP4 promoter (FABP4-Wnt10...
متن کاملExtreme obesity may be linked to markers flanking the human OB gene.
Mice with mutations of the ob gene are extremely obese, and the human homologue (OB) has been cloned and physically mapped. The protein product of the ob gene (leptin) reduces body fat in mice when given exogenously, and leptin has been proposed to provide a lipostatic signal that regulates adiposity. Variation in the OB gene may be one genetically determined cause of obesity in human populatio...
متن کاملIndication for linkage of the human OB gene region with extreme obesity.
Obesity is one of the most significant risk factors for hypertension, coronary heart disease, and NIDDM (Frayn KN, Coppack SW: Insulin resistance, adipose tissue and coronary heart disease. Clin Sci 82:1-8, 1992; Kaplan NM: The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 149:1514-1520, 1989). While family segregation, adoption...
متن کاملRegulation of ob gene expression: evidence for epinephrine-induced suppression in human obesity.
Leptin acts as satiety factor and increases energy expenditure. Studies conducted on animals and in vitro on adipocytes culture have shown that infusion of catecholamines leads to a significant reduction of ob gene expression; it appears of interest to evaluate the in vivo effects of adrenergic activation on the expression of the ob gene in humans. We studied ob gene expression in adipose tissu...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1998
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19980067